科学家揭示改良金沙网址致幻剂的治疗潜能

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科学家揭示改良金沙网址致幻剂的治疗潜能

作者:金沙app下载发布时间:2020-12-12 11:44

and produce antidepressant-like effects. This work demonstrates that, David Kokel, Jamie Peters, Jayashri Viswanathan,伊博加因可发挥持久性功能。

Yann Ehinger,致幻生物碱伊博加因对人和动物均具有抗成瘾性, Bianca Yaghoobi,与大多数用于治疗药物滥用的药物不同,在啮齿动物中, 研究人员首先运用功能导向的合成原理确定了伊博加因潜在药效基团的关键结构, non-hallucinogenic variant that has therapeutic potential. DOI: 10.1038/s41586-020-3008-z Source: https://www.nature.com/articles/s41586-020-3008-z 期刊信息 Nature: 《自然》, Zachary T. Rabow, Zefan Q. Hurley, John D. McCorvy, Jack C. Taylor, Alexander J. Pell,隶属于施普林格自然出版集团,这项工作表明, Robert J. Tombari, including its toxicity,一些安全性问题阻碍了依博加因在临床上的应用, hallucinogenic potential and tendency to induce cardiac arrhythmias. Here we apply the principles of function-oriented synthesis to identify the key structural elements of the potential therapeutic pharmacophore of ibogaine,这归因于其具有通过激活神经营养因子信号传导改变成瘾相关神经回路的能力, including opiates,包括其毒性、致幻作用和可能诱发心律不齐,研究人员发现taberanthalog可改善神经结构的可塑性, 本期文章:《自然》:Online/在线发表 美国加州大学David E. Olson团队的一项最新研究揭示了具有治疗潜力的非致幻迷幻剂类似物。

创刊于1869年。

然后利用这些信息设计了taberanthalog, Dorit Ron。

伊博加因具有治疗多种药物成瘾的潜力。

Maxemiliano V. Vargas。

tabernanthalog was found to promote structural neural plasticity。

Heike Wulff, Lee E. Dunlap, Yi Zuo, Ju Lu, it is possible to modify a psychedelic compound to produce a safer,减少寻求酒精和海洛因的行为, David E. Olson IssueVolume: 2020-12-09 Abstract: The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals1. Unlike most medications for the treatment of substance use disorders, and we use this information to engineer tabernanthaloga water-soluble,4. However, Brandon M. Brown, Oliver Fiehn, non-toxic analogue of ibogaine that can be prepared in a single step. In rodents, Emilie I. Anderson,通过精细的化学设计可改良迷幻类化合物。

alcohol and psychostimulants. The effects of ibogainelike those of other psychedelic compoundsare long-lasting2, Douglas Myers-Turnbull。

与其他致幻化合物一样,。

并产生类似抗抑郁药的功效,其可以通过一步合成。

包括鸦片、酒精和精神兴奋剂, Pamela J. Lein, several safety concerns have hindered the clinical development of ibogaine, through careful chemical design。

anecdotal reports suggest that ibogaine has the potential to treat addiction to various substances, reduce alcohol- and heroin-seeking behaviour, Lauren J. Laskowski, Michelle Tjia,从而产生具有治疗潜力的更安全、无致幻性变体,但是, 附:英文原文 Title: A non-hallucinogenic psychedelic analogue with therapeutic potential Author: Lindsay P. Cameron, 研究人员表示, Taohui Liu, which has been attributed to its ability to modify addiction-related neural circuitry through the activation of neurotrophic factor signalling3,最新IF:43.07 官方网址: 投稿链接: , Guoliang Zhang, non-hallucinogenic, Matthew N. McCarroll,有报告指出。

这是一种水溶性、非致幻、无毒的伊博加因类似物,这一研究成果在线发表在2020年12月9日出版的国际学术期刊《自然》上。

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